Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities. A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in c...

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Publicado no:Biochem Pharmacol
Main Authors: Neelakantan, Harshini, Vance, Virginia, Wetzel, Michael D., Leo Wang, Hua-Yu, McHardy, Stanton F., Finnerty, Celeste C., Hommel, Jonathan D., Watowich, Stanley J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826726/
https://ncbi.nlm.nih.gov/pubmed/29155147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.11.007
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