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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes(1). Adipose-specific knockout or overexpression of Glut4 alters systemic insulin sensitivity(2). Here we show, using DNA array analyses, that nicotinamide N-methyltransferase (Nnmt) is the mos...

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Bibliografische gegevens
Hoofdauteurs: Kraus, Daniel, Yang, Qin, Kong, Dong, Banks, Alexander S., Zhang, Lin, Rodgers, Joseph T., Pirinen, Eija, Pulinilkunnil, Thomas C., Gong, Fengying, Wang, Ya-chin, Cen, Yana, Sauve, Anthony A., Asara, John M., Peroni, Odile D., Monia, Brett P., Bhanot, Sanjay, Alhonen, Leena, Puigserver, Pere, Kahn, Barbara B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107212/
https://ncbi.nlm.nih.gov/pubmed/24717514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13198
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