Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myobla...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Neelakantan, Harshini, Brightwell, Camille R., Graber, Ted G., Maroto, Rosario, Leo Wang, Hua-Yu, McHardy, Stanton F., Papaconstantinou, John, Fry, Christopher S., Watowich, Stanley J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469996/
https://ncbi.nlm.nih.gov/pubmed/30753815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.02.008
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