Skeletal muscle–specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration

mTORC1 regulates protein synthesis and in turn is regulated by growth factors, energy status, and amino acid availability. In kidney cell (HEK293-T) culture, the GAP activity toward RAG (GATOR1) protein complex suppresses activation of the RAG A/B–RAG C/D heterodimer when amino acids are insufficien...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Graber, Ted G., Fry, Christopher S., Brightwell, Camille R., Moro, Tatiana, Maroto, Rosario, Bhattarai, Nisha, Porter, Craig, Wakamiya, Maki, Rasmussen, Blake B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422100/
https://ncbi.nlm.nih.gov/pubmed/30635399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005970
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