A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity

Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells. Here, we show that an indole nucleotide analog, 5-methylcarboxyl-indolyl-2′-deoxyriboside 5′-triphosphate (5-MeCITP), functions as an inhibitor o...

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Publicat a:PLoS Biol
Autors principals: Hernandez-Sanchez, Wilnelly, Huang, Wei, Plucinsky, Brian, Garcia-Vazquez, Nelson, Robinson, Nathaniel J., Schiemann, William P., Berdis, Anthony J., Skordalakes, Emmanuel, Taylor, Derek J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469803/
https://ncbi.nlm.nih.gov/pubmed/30951520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000204
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