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POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length
Telomeres cap the ends of linear chromosomes and terminate in a single-stranded DNA (ssDNA) overhang recognized by POT1-TPP1 heterodimers to help regulate telomere length homeostasis. Here hydroxyl radical footprinting coupled with mass spectrometry was employed to probe protein–protein interactions...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6876245/ https://ncbi.nlm.nih.gov/pubmed/31685617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905381116 |
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