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Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

Eukaryotic up-frameshift 1 (UPF1) is a nucleic acid-dependent ATPase and 5′-to-3′ helicase, best characterized for its roles in cytoplasmic RNA quality control. We previously demonstrated that human UPF1 binds to telomeres in vivo and its depletion leads to telomere instability. Here, we show that U...

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Autori principali: Chawla, Raghav, Redon, Sophie, Raftopoulou, Christina, Wischnewski, Harry, Gagos, Sarantis, Azzalin, Claus M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209776/
https://ncbi.nlm.nih.gov/pubmed/21829167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.280
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