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Functional interaction between telomere protein TPP1 and telomerase

Human chromosome end-capping and telomerase regulation require POT1 (Protection of Telomeres 1) and TPP1 proteins, which bind to the 3′ ssDNA extension of human telomeres. POT1–TPP1 binding to telomeric DNA activates telomerase repeat addition processivity. We now provide evidence that this POT1–TPP...

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Bibliografske podrobnosti
Main Authors: Zaug, Arthur J., Podell, Elaine R., Nandakumar, Jayakrishnan, Cech, Thomas R.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841338/
https://ncbi.nlm.nih.gov/pubmed/20231318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1881810
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