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Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
Eukaryotic up-frameshift 1 (UPF1) is a nucleic acid-dependent ATPase and 5′-to-3′ helicase, best characterized for its roles in cytoplasmic RNA quality control. We previously demonstrated that human UPF1 binds to telomeres in vivo and its depletion leads to telomere instability. Here, we show that U...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209776/ https://ncbi.nlm.nih.gov/pubmed/21829167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.280 |
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