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Structural Determinants of Isoform Selectivity in PI3K Inhibitors
Phosphatidylinositol 3-kinases (PI3Ks) are important therapeutic targets for the treatment of cancer, thrombosis, and inflammatory and immune diseases. The four highly homologous Class I isoforms, PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ have unique, non-redundant physiological roles and as such, isoform selec...
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| Publicado no: | Biomolecules |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6468644/ https://ncbi.nlm.nih.gov/pubmed/30813656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9030082 |
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