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l-Aminoacyl-triazine Derivatives Are Isoform-Selective PI3Kβ Inhibitors That Target Nonconserved Asp862 of PI3Kβ
[Image: see text] A series of aminoacyl-triazine derivatives based upon the pan-PI3K inhibitor ZSTK474 were identified as potent and isoform-selective inhibitors of PI3Kβ. The compounds showed selectivity based upon stereochemistry with l-amino acyl derivatives preferring PI3Kβ, while their d-congen...
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| Main Authors: | , , , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American
Chemical Society
2012
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| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688631/ https://ncbi.nlm.nih.gov/pubmed/23795239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300336j |
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