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PI3K isoform-selective inhibitors: next-generation targeted cancer therapies
The pivotal roles of phosphatidylinositol 3-kinases (PI3Ks) in human cancers have inspired active development of small molecules to inhibit these lipid kinases. However, the first-generation pan-PI3K and dual-PI3K/mTOR inhibitors have encountered problems in clinical trials, with limited efficacies...
में बचाया:
| में प्रकाशित: | Acta Pharmacol Sin |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4648175/ https://ncbi.nlm.nih.gov/pubmed/26364801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.71 |
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