Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury

[Image: see text] Acetaminophen misuse is a leading cause of acute liver failure and liver transplantation for which therapy is poorly effective. FXR ligands have shown effective in reducing liver injury in several experimental and clinical settings. In this Letter, we have elaborated on the structu...

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Udgivet i:ACS Med Chem Lett
Main Authors: Sepe, Valentina, Marchianò, Silvia, Finamore, Claudia, Baronissi, Giuliana, Di Leva, Francesco Saverio, Carino, Adriana, Biagioli, Michele, Fiorucci, Chiara, Cassiano, Chiara, Monti, Maria Chiara, del Gaudio, Federica, Novellino, Ettore, Limongelli, Vittorio, Fiorucci, Stefano, Zampella, Angela
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466548/
https://ncbi.nlm.nih.gov/pubmed/30996771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00423
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