Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

[Image: see text] Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In t...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Festa, Carmen, Finamore, Claudia, Marchianò, Silvia, Di Leva, Francesco Saverio, Carino, Adriana, Monti, Maria Chiara, del Gaudio, Federica, Ceccacci, Sara, Limongelli, Vittorio, Zampella, Angela, Fiorucci, Stefano, De Marino, Simona
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466555/
https://ncbi.nlm.nih.gov/pubmed/30996787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00534
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