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Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

Bile acid (BA) receptors represent well-defined targets for the development of novel therapeutic approaches to metabolic and inflammatory diseases. In the present study, we report the generation of novel C-3 modified 6-ethylcholane derivatives. The pharmacological characterization and molecular dock...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Festa, Carmen, De Marino, Simona, Carino, Adriana, Sepe, Valentina, Marchianò, Silvia, Cipriani, Sabrina, Di Leva, Francesco S., Limongelli, Vittorio, Monti, Maria C., Capolupo, Angela, Distrutti, Eleonora, Fiorucci, Stefano, Zampella, Angela
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371667/
https://ncbi.nlm.nih.gov/pubmed/28424617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00162
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