Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Bile acids can regulate nutrient metabolism through the activation of the cell membrane receptor GPBAR1 and the nuclear receptor FXR. Developing an exogenous control over these receptors represents an attractive strategy for the treatment of enterohepatic and metabolic disorders. A number of dual GP...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Di Leva, Francesco Saverio, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Novellino, Ettore, Fiorucci, Stefano, Zampella, Angela, Limongelli, Vittorio
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645117/
https://ncbi.nlm.nih.gov/pubmed/26567894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16605
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