Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Bile acids can regulate nutrient metabolism through the activation of the cell membrane receptor GPBAR1 and the nuclear receptor FXR. Developing an exogenous control over these receptors represents an attractive strategy for the treatment of enterohepatic and metabolic disorders. A number of dual GP...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Di Leva, Francesco Saverio, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Novellino, Ettore, Fiorucci, Stefano, Zampella, Angela, Limongelli, Vittorio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645117/
https://ncbi.nlm.nih.gov/pubmed/26567894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16605
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