GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis

[Image: see text] GPBAR1 agonists have been identified as potential leads for the treatment of diseases related to colon inflammation such as Crohn’s and ulcerative colitis. In this paper, we report the discovery of a small library of hyodeoxycholane analogues, decorated at C-6 with different substi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Marino, Simona De, Finamore, Claudia, Biagioli, Michele, Carino, Adriana, Marchianò, Silvia, Roselli, Rosalinda, Giorgio, Cristina Di, Bordoni, Martina, Di Leva, Francesco Saverio, Novellino, Ettore, Cassiano, Chiara, Limongelli, Vittorio, Zampella, Angela, Festa, Carmen, Fiorucci, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236273/
https://ncbi.nlm.nih.gov/pubmed/32435390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00636
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