Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

Bile acids are signaling molecules interacting with nuclear receptors and membrane G-protein-coupled receptors. Among these receptors, the farnesoid X receptor (FXR) and the membrane G-coupled receptor (GPBAR1) have gained increasing consideration as druggable receptors and their exogenous dual regu...

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Udgivet i:Sci Rep
Main Authors: Finamore, Claudia, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Carino, Adriana, Masullo, Dario, Biagioli, Michele, Marchianò, Silvia, Capolupo, Angela, Monti, Maria Chiara, Fiorucci, Stefano, Zampella, Angela
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933954/
https://ncbi.nlm.nih.gov/pubmed/27381677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29320
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