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Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists
Bile acids are the endogenous modulators of the nuclear receptor FXR and the membrane receptor GPBAR1. FXR represents a promising pharmacological target for the treatment of cholestatic liver disorders. Currently available semisynthetic bile acid derivatives cover the same chemical space of bile aci...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704022/ https://ncbi.nlm.nih.gov/pubmed/26740187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19008 |
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