Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists

Bile acids are the endogenous modulators of the nuclear receptor FXR and the membrane receptor GPBAR1. FXR represents a promising pharmacological target for the treatment of cholestatic liver disorders. Currently available semisynthetic bile acid derivatives cover the same chemical space of bile aci...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Sci Rep
Main Authors: Sepe, Valentina, Festa, Carmen, Renga, Barbara, Carino, Adriana, Cipriani, Sabrina, Finamore, Claudia, Masullo, Dario, del Gaudio, Federica, Monti, Maria Chiara, Fiorucci, Stefano, Zampella, Angela
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704022/
https://ncbi.nlm.nih.gov/pubmed/26740187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19008
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla