Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H(2)S Generation and Endothelin-1

BACKGROUND: GPBAR1 is a bile acids activated receptor expressed in entero-hepatic tissues. In the liver expression of GPBAR1 is restricted to sinusoidal and Kuppfer cells. In the systemic circulation vasodilation caused by GPBAR1 agonists is abrogated by inhibition of cystathione-γ-liase (CSE), an e...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Renga, Barbara, Cipriani, Sabrina, Carino, Adriana, Simonetti, Michele, Zampella, Angela, Fiorucci, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634759/
https://ncbi.nlm.nih.gov/pubmed/26539823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141082
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