Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

BACKGROUND & AIMS: In cholestatic syndromes, body accumulation of bile acids is thought to cause itching. However, the mechanisms supporting this effect remain elusive. Recently, GPBAR1 (TGR5) a G-protein coupled receptor has been shown to mediate itching caused by intradermal administration of...

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Foilsithe in:PLoS One
Main Authors: Cipriani, Sabrina, Renga, Barbara, D’Amore, Claudio, Simonetti, Michele, De Tursi, Antonio Angelo, Carino, Adriana, Monti, Maria Chiara, Sepe, Valentina, Zampella, Angela, Fiorucci, Stefano
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503431/
https://ncbi.nlm.nih.gov/pubmed/26177448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129866
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