Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

BACKGROUND: The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastrointestinal tract. Despite FXR ligands are under investigation for treatment of cholestasis, a biochemical condition occurring in a number of liver diseases for which available therapies are poorly effec...

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Detalhes bibliográficos
Main Authors: Renga, Barbara, Mencarelli, Andrea, D'Amore, Claudio, Cipriani, Sabrina, D'Auria, Maria Valeria, Sepe, Valentina, Chini, Maria Giovanna, Monti, Maria Chiara, Bifulco, Giuseppe, Zampella, Angela, Fiorucci, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264597/
https://ncbi.nlm.nih.gov/pubmed/22291955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030443
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