Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-...

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Main Authors: Sepe, Valentina, Ummarino, Raffaella, D’Auria, Maria Valeria, Taglialatela-Scafati, Orazio, Marino, Simona De, D’Amore, Claudio, Renga, Barbara, Chini, Maria Giovanna, Bifulco, Giuseppe, Nakao, Yoichi, Fusetani, Nobuhiro, Fiorucci, Stefano, Zampella, Angela
Format: Artigo
Language:Inglês
Published: MDPI 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509528/
https://ncbi.nlm.nih.gov/pubmed/23203270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md10112448
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