Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Accumulation of mutated superoxide dismutase 1 (mSOD1) in amyotrophic lateral sclerosis (ALS) involves injury to motor neurons (MNs), activation of glial cells and immune unbalance. However, neuroinflammation, besides its detrimental effects, also plays beneficial roles in ALS pathophysiology. There...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Vaz, Ana Rita, Pinto, Sara, Ezequiel, Catarina, Cunha, Carolina, Carvalho, Luís A., Moreira, Rui, Brites, Dora
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465643/
https://ncbi.nlm.nih.gov/pubmed/31024256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00109
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