Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Accumulation of mutated superoxide dismutase 1 (mSOD1) in amyotrophic lateral sclerosis (ALS) involves injury to motor neurons (MNs), activation of glial cells and immune unbalance. However, neuroinflammation, besides its detrimental effects, also plays beneficial roles in ALS pathophysiology. There...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Cell Neurosci
Main Authors: Vaz, Ana Rita, Pinto, Sara, Ezequiel, Catarina, Cunha, Carolina, Carvalho, Luís A., Moreira, Rui, Brites, Dora
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465643/
https://ncbi.nlm.nih.gov/pubmed/31024256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00109
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