Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Accumulation of mutated superoxide dismutase 1 (mSOD1) in amyotrophic lateral sclerosis (ALS) involves injury to motor neurons (MNs), activation of glial cells and immune unbalance. However, neuroinflammation, besides its detrimental effects, also plays beneficial roles in ALS pathophysiology. There...

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Publicat a:Front Cell Neurosci
Autors principals: Vaz, Ana Rita, Pinto, Sara, Ezequiel, Catarina, Cunha, Carolina, Carvalho, Luís A., Moreira, Rui, Brites, Dora
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465643/
https://ncbi.nlm.nih.gov/pubmed/31024256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00109
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