Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. Exosomal transfer of mutant copper-zinc superoxide...

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Dades bibliogràfiques
Publicat a:Front Neurosci
Autors principals: Pinto, Sara, Cunha, Carolina, Barbosa, Marta, Vaz, Ana R., Brites, Dora
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434170/
https://ncbi.nlm.nih.gov/pubmed/28567000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00273
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