Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1(G93A) Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice

Dominant mutations in the Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons. The molecular mechanism underlying the toxic gain-of-function of mutant hSOD1s remains uncertain. Several...

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Bibliographic Details
Main Authors: Pehar, Mariana, Beeson, Gyda, Beeson, Craig C., Johnson, Jeffrey A., Vargas, Marcelo R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108402/
https://ncbi.nlm.nih.gov/pubmed/25054289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103438
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