Tempol Moderately Extends Survival in a hSOD1(G93A) ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1(G93A) Forms

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive dysfunction and death of motor neurons by mechanisms that remain unclear. Evidence indicates that oxidative mechanisms contribute to ALS pathology, but classical antioxidants have not performed...

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Main Authors: Linares, Edlaine, Seixas, Luciana V., dos Prazeres, Janaina N., Ladd, Fernando V. L., Ladd, Aliny A. B. L., Coppi, Antonio A., Augusto, Ohara
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566093/
https://ncbi.nlm.nih.gov/pubmed/23405225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055868
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