Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular expression pattern and release toxic factors that contribute to neurodegeneration and microglial activation. We and others identified a dysregulated inflammatory miRNA profile in ALS patients and in mice models suggest...

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Detalles Bibliográficos
Publicado en:Front Cell Dev Biol
Main Authors: Barbosa, Marta, Gomes, Cátia, Sequeira, Catarina, Gonçalves-Ribeiro, Joana, Pina, Carolina Campos, Carvalho, Luís A., Moreira, Rui, Vaz, Sandra H., Vaz, Ana Rita, Brites, Dora
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103001/
https://ncbi.nlm.nih.gov/pubmed/33968923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.634355
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