Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

Reactive astrocytes in Amyotrophic Lateral Sclerosis (ALS) change their molecular expression pattern and release toxic factors that contribute to neurodegeneration and microglial activation. We and others identified a dysregulated inflammatory miRNA profile in ALS patients and in mice models suggest...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Barbosa, Marta, Gomes, Cátia, Sequeira, Catarina, Gonçalves-Ribeiro, Joana, Pina, Carolina Campos, Carvalho, Luís A., Moreira, Rui, Vaz, Sandra H., Vaz, Ana Rita, Brites, Dora
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103001/
https://ncbi.nlm.nih.gov/pubmed/33968923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.634355
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados