Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity

We have shown previously that the process of replication machinery (replisome) disassembly at the termination of DNA replication forks in the S-phase is driven through polyubiquitylation of one of the replicative helicase subunits (Mcm7) by Cul2(LRR1) ubiquitin ligase. Interestingly, upon inhibition...

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Bibliographic Details
Published in:Life Sci Alliance
Main Authors: Priego Moreno, Sara, Jones, Rebecca M, Poovathumkadavil, Divyasree, Scaramuzza, Shaun, Gambus, Agnieszka
Format: Artigo
Language:Inglês
Published: Life Science Alliance LLC 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6464043/
https://ncbi.nlm.nih.gov/pubmed/30979826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900390
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