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CUL-2(LRR-1) and UBXN-3/FAF1 drive replisome disassembly during DNA replication termination and mitosis
Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (Cdc45-MCM-GINS). Using Caenorhabditis elegans early embryos and Xenopus egg extracts, we show that the E3 ligase CUL-2(LRR-1) associates with th...
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| Vydáno v: | Nat Cell Biol |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5410169/ https://ncbi.nlm.nih.gov/pubmed/28368371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3500 |
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