LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components

After two converging DNA replication forks meet, active replisomes are disassembled and unloaded from chromatin. A key process in replisome disassembly is the unloading of CMG helicases (CDC45–MCM–GINS), which is initiated in Caenorhabditis elegans and Xenopus laevis by the E3 ubiquitin ligase CRL2(...

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Udgivet i:J Cell Biol
Main Authors: Fan, Yilin, Köberlin, Marielle S., Ratnayeke, Nalin, Liu, Chad, Deshpande, Madhura, Gerhardt, Jeannine, Meyer, Tobias
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160578/
https://ncbi.nlm.nih.gov/pubmed/34037657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202009147
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