TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis with regions of incompletely replicated DNA. These r...

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Bibliographic Details
Published in:eLife
Main Authors: Sonneville, Remi, Bhowmick, Rahul, Hoffmann, Saskia, Mailand, Niels, Hickson, Ian D, Labib, Karim
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Chromosomes and Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773462/
https://ncbi.nlm.nih.gov/pubmed/31545170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48686
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