CUL-2(LRR-1) and UBXN-3/FAF1 drive replisome disassembly during DNA replication termination and mitosis

Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (Cdc45-MCM-GINS). Using Caenorhabditis elegans early embryos and Xenopus egg extracts, we show that the E3 ligase CUL-2(LRR-1) associates with th...

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Udgivet i:Nat Cell Biol
Main Authors: Sonneville, Remi, Priego Moreno, Sara, Knebel, Axel, Johnson, Clare, Hastie, C. James, Gartner, Anton, Gambus, Agnieszka, Labib, Karim
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410169/
https://ncbi.nlm.nih.gov/pubmed/28368371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3500
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