Human cytomegalovirus-specific T-cell receptor engineered for high affinity and soluble expression using mammalian cell display

T-cell receptors (TCR) have considerable potential as therapeutics and antibody-like reagents to monitor disease progression and vaccine efficacy. Whereas antibodies recognize only secreted and surface-bound proteins, TCRs recognize otherwise inaccessible disease-associated intracellular proteins wh...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Wagner, Ellen K., Qerqez, Ahlam N., Stevens, Christopher A., Nguyen, Annalee W., Delidakis, George, Maynard, Jennifer A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463697/
https://ncbi.nlm.nih.gov/pubmed/30796163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007187
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