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Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display
We here report a novel phage display selection strategy enabling fast and easy selection of thermostabilized proteins. The approach is illustrated with stabilization of an aggregation-prone soluble single chain T cell receptor (scTCR) characteristic of the murine MOPC315 myeloma model. Random mutati...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557450/ https://ncbi.nlm.nih.gov/pubmed/23362461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01162 |
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