Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investi...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Lodge, Emily J, Santambrogio, Alice, Russell, John P, Xekouki, Paraskevi, Jacques, Thomas S, Johnson, Randy L, Thavaraj, Selvam, Bornstein, Stefan R, Andoniadou, Cynthia Lilian
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2019
Ämnen:
Stem Cells and Regenerative Medicine
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461440/
https://ncbi.nlm.nih.gov/pubmed/30912742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43996
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