Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investi...

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Опубликовано в: :eLife
Главные авторы: Lodge, Emily J, Santambrogio, Alice, Russell, John P, Xekouki, Paraskevi, Jacques, Thomas S, Johnson, Randy L, Thavaraj, Selvam, Bornstein, Stefan R, Andoniadou, Cynthia Lilian
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2019
Предметы:
Stem Cells and Regenerative Medicine
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461440/
https://ncbi.nlm.nih.gov/pubmed/30912742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43996
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