Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lodge, Emily J, Santambrogio, Alice, Russell, John P, Xekouki, Paraskevi, Jacques, Thomas S, Johnson, Randy L, Thavaraj, Selvam, Bornstein, Stefan R, Andoniadou, Cynthia Lilian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Stem Cells and Regenerative Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461440/
https://ncbi.nlm.nih.gov/pubmed/30912742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43996
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