Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

Malignant peripheral nerve-sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage-derived sarcomas. Molecular events driving SC-to-MPNST transformation are incompletely understood. Here, we show that human MPNSTs exhibit elevated HIPPO-TAZ/YAP expression, and that TAZ/YAP hyperactivi...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Wu, Lai Man Natalie, Deng, Yaqi, Wang, Jincheng, Zhao, Chuntao, Wang, Jiajia, Rao, Rohit, Xu, Lingli, Zhou, Wenhao, Choi, Kwangmin, Rizvi, Tilat A., Remke, Marc, Rubin, Joshua, Johnson, Randy, Carroll, Thomas, Stemmer-Rachamimov, Anat O., Wu, Jianqiang, Zheng, Yi, Xin, Mei, Ratner, Nancy, Lu, Q. Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813693/
https://ncbi.nlm.nih.gov/pubmed/29438698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.005
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