Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

Malignant peripheral nerve-sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage-derived sarcomas. Molecular events driving SC-to-MPNST transformation are incompletely understood. Here, we show that human MPNSTs exhibit elevated HIPPO-TAZ/YAP expression, and that TAZ/YAP hyperactivi...

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Vydáno v:Cancer Cell
Hlavní autoři: Wu, Lai Man Natalie, Deng, Yaqi, Wang, Jincheng, Zhao, Chuntao, Wang, Jiajia, Rao, Rohit, Xu, Lingli, Zhou, Wenhao, Choi, Kwangmin, Rizvi, Tilat A., Remke, Marc, Rubin, Joshua, Johnson, Randy, Carroll, Thomas, Stemmer-Rachamimov, Anat O., Wu, Jianqiang, Zheng, Yi, Xin, Mei, Ratner, Nancy, Lu, Q. Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813693/
https://ncbi.nlm.nih.gov/pubmed/29438698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.005
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