Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investi...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Lodge, Emily J, Santambrogio, Alice, Russell, John P, Xekouki, Paraskevi, Jacques, Thomas S, Johnson, Randy L, Thavaraj, Selvam, Bornstein, Stefan R, Andoniadou, Cynthia Lilian
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Stem Cells and Regenerative Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461440/
https://ncbi.nlm.nih.gov/pubmed/30912742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43996
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