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Methionine Oxidation Changes the Mechanism of Aβ Peptide Binding to the DMPC Bilayer
Using all-atom explicit solvent replica exchange molecular dynamics simulations with solute tempering, we study the effect of methionine oxidation on Aβ10–40 peptide binding to the zwitterionic DMPC bilayer. By comparing oxidized and reduced peptides, we identified changes in the binding mechanism c...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459879/ https://ncbi.nlm.nih.gov/pubmed/30976055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42304-9 |
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