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De novo aggregation of Alzheimer’s Aβ25-35 peptides in a lipid bilayer

A potential mechanism of cytotoxicity attributed to Alzheimer’s Aβ peptides postulates that their aggregation disrupts membrane structure causing uncontrollable permeation of Ca(2+) ions. To gain molecular insights into these processes, we have performed all-atom explicit solvent replica exchange wi...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Smith, Amy K., Klimov, Dmitri K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509337/
https://ncbi.nlm.nih.gov/pubmed/31073226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43685-7
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