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Methionine Oxidation Changes the Mechanism of Aβ Peptide Binding to the DMPC Bilayer
Using all-atom explicit solvent replica exchange molecular dynamics simulations with solute tempering, we study the effect of methionine oxidation on Aβ10–40 peptide binding to the zwitterionic DMPC bilayer. By comparing oxidized and reduced peptides, we identified changes in the binding mechanism c...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459879/ https://ncbi.nlm.nih.gov/pubmed/30976055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42304-9 |
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