Molecular Interactions of Alzheimer's Biomarker FDDNP with Aβ Peptide

All-atom explicit solvent model and replica exchange molecular dynamics were used to investigate binding of Alzheimer's biomarker FDDNP to the Aβ(10–40) monomer. At low and high concentrations, FDDNP binds with high affinity to two sites in the Aβ(10–40) monomer located near the central hydroph...

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Bibliographic Details
Main Authors: Lockhart, Christopher, Klimov, Dmitri K.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2012
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514529/
https://ncbi.nlm.nih.gov/pubmed/23283233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.003
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