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Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain transcriptional programs and ensure cellular identity. PRC2 methylates lysine 27 on histone H3 (H3K27me), while PRC1 mono-ubiquitinates histone H2A at lysine 119 (H2Aub1). Here we present engineered mouse...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459869/ https://ncbi.nlm.nih.gov/pubmed/30976011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09624-w |
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