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Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity

The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain transcriptional programs and ensure cellular identity. PRC2 methylates lysine 27 on histone H3 (H3K27me), while PRC1 mono-ubiquitinates histone H2A at lysine 119 (H2Aub1). Here we present engineered mouse...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Lavarone, Elisa, Barbieri, Caterina M., Pasini, Diego
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459869/
https://ncbi.nlm.nih.gov/pubmed/30976011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09624-w
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