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Kinetic Understanding of N(2) Reduction versus H(2) Evolution at the E(4)(4H) Janus State in the Three Nitrogenases

The enzyme nitrogenase catalyzes the reduction of N(2) to ammonia but also that of protons to H(2). These reactions compete at the mechanistically central ‘Janus’ intermediate, denoted E(4)(4H), which has accumulated 4e(−)/4H(+) as two bridging Fe-H—Fe hydrides on the active-site cofactor. This stat...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Harris, Derek F., Yang, Zhi-Yong, Dean, Dennis R., Seefeldt, Lance C., Hoffman, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459397/
https://ncbi.nlm.nih.gov/pubmed/30183278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00784
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