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Reductive Elimination of H(2) Activates Nitrogenase to Reduce the N≡N Triple Bond: Characterization of the E(4)(4H) Janus Intermediate in Wild-Type Enzyme
We have proposed a reductive elimination/oxidative addition (re/oa) mechanism for reduction of N(2) to 2NH(3) by nitrogenase, based on identification of a freeze-trapped intermediate of the α-70(Val→Ile) substituted MoFe protein as the Janus intermediate that stores four reducing equivalents on FeMo...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5024552/ https://ncbi.nlm.nih.gov/pubmed/27529724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06362 |
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