Dual use of hematopoietic and mesenchymal stem cells enhances engraftment and immune cell trafficking in an allogeneic humanized mouse model of head and neck cancer

The need for more representative tools to investigate the human tumor microenvironment (TME) has led to the development of humanized mouse models. However, the difficulty of immune system engraftment and minimal human immune cell infiltration into implanted xenografts are major challenges. We have d...

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Veröffentlicht in:Mol Carcinog
Hauptverfasser: Morton, J. Jason, Keysar, Stephen B., Perrenoud, Loni, Chimed, Tugs-Saikhan, Reisinger, Julie, Jackson, Brian, Le, Phuong N., Nieto, Cera, Gomez, Karina, Miller, Bettina, Gao, Dexiang, Somerset, Hilary, Wang, Xiao-Jing, Jimeno, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452868/
https://ncbi.nlm.nih.gov/pubmed/30129680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22887
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